{"id":26973,"date":"2018-07-10T10:00:07","date_gmt":"2018-07-10T13:00:07","guid":{"rendered":"http:\/\/farmaciaproderma.com.br\/blog\/?p=26973"},"modified":"2018-04-12T17:08:12","modified_gmt":"2018-04-12T20:08:12","slug":"ajuste-em-doses-de-medicamentos-industrializados","status":"publish","type":"post","link":"https:\/\/farmaciaproderma.com.br\/blog\/ajuste-em-doses-de-medicamentos-industrializados\/","title":{"rendered":"Ajuste em doses de medicamentos industrializados"},"content":{"rendered":"

[et_pb_section bb_built=”1″ fullwidth=”on” specialty=”off” transparent_background=”off” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”off” padding_mobile=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”off” background_color=”#ffffff” custom_padding_tablet=”50px|0|50px|0″ custom_padding_last_edited=”on|desktop” global_module=”25413″][et_pb_fullwidth_post_title global_parent=”25413″ title=”on” meta=”off” author=”off” date=”on” categories=”on” comments=”off” featured_image=”on” featured_placement=”background” parallax_effect=”off” parallax_method=”off” text_orientation=”center” text_color=”dark” text_background=”on” text_bg_color=”rgba(255,255,255,0.9)” module_bg_color=”rgba(255,255,255,0)” title_all_caps=”off” use_border_color=”off” border_color=”#ffffff” border_style=”solid” custom_padding=”300px||300px|” title_font=”Montserrat||||” title_font_size_last_edited=”on|phone” title_text_color=”#29166f” title_font_size=”50px” title_font_size_tablet=”26px” custom_padding_tablet=”150px||150px|” custom_padding_last_edited=”on|phone” custom_padding_phone=”50px||50px|” disabled=”off” disabled_on=”on|on|” background_color=”rgba(255,255,255,0)” \/][et_pb_fullwidth_post_title admin_label=”Mobile” global_parent=”25413″ title=”on” meta=”off” author=”on” date=”on” categories=”on” comments=”on” featured_image=”on” featured_placement=”above” text_orientation=”center” text_color=”dark” text_background=”on” use_border_color=”off” custom_padding=”300px||300px|” title_font=”Montserrat||||” title_font_size_last_edited=”on|desktop” title_text_color=”#29166f” title_font_size=”50px” title_font_size_tablet=”26px” custom_padding_tablet=”0px||0px|” custom_padding_last_edited=”on|phone” disabled=”off” disabled_on=”off|off|on” parallax=”on” background_color=”rgba(255,255,255,0)” _builder_version=”3.0.100″ custom_margin=”||-30px|” \/][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”off” specialty=”off” transparent_background=”off” background_color=”#ffffff” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”off” padding_mobile=”on” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”off” custom_padding=”0px||0px|”][et_pb_row make_fullwidth=”off” use_custom_width=”on” width_unit=”off” use_custom_gutter=”off” padding_mobile=”on” allow_player_pause=”off” parallax=”off” parallax_method=”off” make_equal=”off” parallax_1=”off” parallax_method_1=”off” column_padding_mobile=”on” custom_width_percent=”40%” custom_margin_last_edited=”off|phone” custom_padding=”||0px|”][et_pb_column type=”4_4″][et_pb_text background_layout=”light” use_border_color=”off” border_color=”#ffffff” border_style=”solid” header_font_size_phone=”60px” header_font_size_last_edited=”on|phone” module_class=”letra” _builder_version=”3.0.100″]<\/p>\n

Farmac\u00eauticos altamente especializados podem ajustar doses de medicamentos industrializados j\u00e1 prontos <\/strong><\/p>\n

A cena \u00e9 comum: um comprimido tem uma concentra\u00e7\u00e3o mais alta que o necess\u00e1rio para o paciente e precisa ser partido ao meio (ou em mais partes). Outras vezes, \u00e9 o conte\u00fado em p\u00f3 de uma c\u00e1psula que precisa ser dilu\u00eddo na \u00e1gua ou o comprimido que precisa ser pulverizado por tritura\u00e7\u00e3o, j\u00e1 que a crian\u00e7a n\u00e3o consegue engolir na forma s\u00f3lida. Do ponto de vista farmac\u00eautico, essa \u00e9 uma quest\u00e3o cr\u00edtica, pois gera imprecis\u00e3o na dose do medicamento. Al\u00e9m disso, pode alterar significativamente a estabilidade e as propriedades qu\u00edmicas, toxol\u00f3gicas e terap\u00eauticas, comprometendo a efic\u00e1cia e seguran\u00e7a.<\/p>\n

Diante disso, quando n\u00e3o h\u00e1 disponibilidade do insumo para prepara\u00e7\u00e3o direta, \u00e9 essencial o trabalho profissional do farmac\u00eautico qualificado na transforma\u00e7\u00e3o. Esse processo ocorre quando o medicamento industrializado tem sua dose, concentra\u00e7\u00e3o ou forma farmac\u00eautica ajustada por meio de opera\u00e7\u00f5es farmac\u00eauticas – como parti\u00e7\u00e3o, tritura\u00e7\u00e3o e dispers\u00e3o – que modificam a apresenta\u00e7\u00e3o original, incluindo ou n\u00e3o a convers\u00e3o em outra forma farmac\u00eautica. Pode-se, por exemplo, transformar um comprimido em suspens\u00e3o l\u00edquida para atender necessidades espec\u00edficas e possibilitar a ades\u00e3o ao tratamento farmacoterap\u00eautico.<\/p>\n

Assim, garante-se a seguran\u00e7a e a efic\u00e1cia do medicamento destinado para o paciente. A transforma\u00e7\u00e3o \u00e9 muito comum no cen\u00e1rio de hospitais e, em v\u00e1rios casos, para uso domiciliar. Um dos contextos em que a transforma\u00e7\u00e3o \u00e9 mais pertinente \u00e9 nos medicamentos pedi\u00e1tricos, pois h\u00e1 escassez de medicamentos adequados \u00e0s necessidades de neonatos, beb\u00eas e crian\u00e7as, como as prepara\u00e7\u00f5es orais l\u00edquidas. A maioria das crian\u00e7as menores de seis anos n\u00e3o consegue engolir comprimidos ou c\u00e1psulas. Entretanto, somente uma pequena parte dos f\u00e1rmacos est\u00e1 dispon\u00edvel como especialidade farmac\u00eautica na forma de prepara\u00e7\u00f5es l\u00edquidas, menos ainda as pedi\u00e1tricas. A maioria dos medicamentos industrializados s\u00e3o, por motivos mercadol\u00f3gicos ou de estabilidade, comercializados exclusivamente em formas farmac\u00eauticas s\u00f3lidas, como comprimidos e c\u00e1psulas com doses destinadas \u00e0 popula\u00e7\u00e3o adulta.<\/p>\n

Por isso a transforma\u00e7\u00e3o \u00e9 mesmo necess\u00e1ria, mas requer conhecimento espec\u00edfico. O risco est\u00e1 na transforma\u00e7\u00e3o feita de forma caseira pelos pr\u00f3prios pacientes.<\/p>\n

Transformar em qu\u00ea?<\/strong><\/p>\n

Parti\u00e7\u00e3o, tritura\u00e7\u00e3o, fracionamento, dissolu\u00e7\u00e3o: a maneira mais adequada vai depender da necessidade do paciente e da forma em que o produto industrializado est\u00e1 apresentado.<\/p>\n

A estabilidade \u00e9 uma das caracter\u00edsticas essenciais que precisa ser mantida durante a transforma\u00e7\u00e3o de um medicamento. Assim, antes de alterar, \u00e9 preciso consultar na literatura t\u00e9cnica os estudos que garantam que a altera\u00e7\u00e3o desejada pode ser realizada. As transforma\u00e7\u00f5es ocorrem a partir de diversas formas farmac\u00eauticas, sendo que a mais comum para as crian\u00e7as \u00e9 partir do comprimido para a forma l\u00edquida. Mas \u00e9 importante lembrar que o medicamento s\u00f3lido (c\u00e1psulas e comprimidos), quando triturado juntamente com seus excipientes e disperso em um ve\u00edculo l\u00edquido, pode promover altera\u00e7\u00f5es na formula\u00e7\u00e3o transformada. Excipientes comuns em comprimidos, por exemplo, podem alterar o pH de formula\u00e7\u00f5es l\u00edquidas, afetando perfil de estabilidade.<\/p>\n

\u00c9 fundamental que o profissional esteja atento aos potenciais problemas que podem ocorrer durante uma transforma\u00e7\u00e3o de especialidade farmac\u00eautica e assegurar que a prepara\u00e7\u00e3o extempor\u00e2nea resultante apresente conformidade com a dose prescrita, possua atributos de uniformidade e homogeneidade adequados e mantenha-se est\u00e1vel durante o per\u00edodo de tratamento.<\/p>\n

Na Proderma, os farmac\u00eauticos s\u00e3o especializados e altamente qualificados para realizar tais procedimentos. Venha at\u00e9 uma de nossas unidades com o seu medicamento que necessita de ajustes e conte com o nosso profissionalismo para transformar sua f\u00f3rmula de maneira segura e eficaz.<\/p>\n

Texto original: Revista Anfarmag n\u00ba112<\/p>\n

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F\u00f3rmulas com qualidade comprovada pela Associa\u00e7\u00e3o Nacional de Farmac\u00eauticos Magistrais (SINAMM).<\/strong><\/p>\n

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Contate agora mesmo a nossa Equipe Farmac\u00eautica!<\/h2>\n

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Importante<\/h2>\n

O texto acima foi elaborado com base em estudos cient\u00edficos, por\u00e9m salientamos que o conte\u00fado \u00e9 apenas de car\u00e1ter informativo. Antes de adquirir e fazer uso do produto \u00e9 importante consultar um profissional habilitado (seu m\u00e9dico ou nutricionista) ou os farmac\u00eauticos Proderma. Envie um email ou entre em contato com as nossas lojas pelos telefones (19) 3447-7000 e 3421-2112.<\/p>\n

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