[et_pb_section admin_label=”Se\u00e7\u00e3o” global_module=”25413″ fullwidth=”on” specialty=”off” transparent_background=”off” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”off” padding_mobile=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”off” background_color=”#ffffff”][et_pb_fullwidth_post_title global_parent=”25413″ admin_label=”T\u00edtulo da Publica\u00e7\u00e3o de Largura Inteira” title=”on” meta=”off” author=”off” date=”on” categories=”on” comments=”off” featured_image=”on” featured_placement=”background” parallax_effect=”off” parallax_method=”on” text_orientation=”center” text_color=”dark” text_background=”on” text_bg_color=”rgba(255,255,255,0.9)” module_bg_color=”rgba(255,255,255,0)” title_all_caps=”off” use_border_color=”off” border_color=”#ffffff” border_style=”solid” custom_padding=”300px||300px|” title_font=”Montserrat||||” title_font_size_last_edited=”on|phone” title_text_color=”#29166f” title_font_size=”50px” title_font_size_tablet=”26px” custom_padding_tablet=”150px||150px|” custom_padding_last_edited=”on|phone” custom_padding_phone=”50px||50px|” disabled=”off” disabled_on=”on|on|”] [\/et_pb_fullwidth_post_title][et_pb_fullwidth_post_title global_parent=”25413″ admin_label=”Mobile” title=”on” meta=”off” author=”on” date=”on” categories=”on” comments=”on” featured_image=”on” featured_placement=”above” parallax_effect=”on” parallax_method=”on” text_orientation=”center” text_color=”dark” text_background=”on” text_bg_color=”rgba(255,255,255,0.9)” module_bg_color=”rgba(255,255,255,0)” title_all_caps=”off” use_border_color=”off” border_color=”#ffffff” border_style=”solid” custom_padding=”300px||300px|” title_font=”Montserrat||||” title_font_size_last_edited=”on|desktop” title_text_color=”#29166f” title_font_size=”50px” title_font_size_tablet=”26px” custom_padding_tablet=”0px||0px|” custom_padding_last_edited=”on|phone” disabled=”off” disabled_on=”off|off|on”] [\/et_pb_fullwidth_post_title][\/et_pb_section][et_pb_section admin_label=”Se\u00e7\u00e3o” fullwidth=”off” specialty=”off” transparent_background=”off” background_color=”#ffffff” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”off” padding_mobile=”on” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”off” custom_padding=”0px||0px|”][et_pb_row admin_label=”Linha” make_fullwidth=”off” use_custom_width=”on” width_unit=”off” use_custom_gutter=”off” padding_mobile=”on” allow_player_pause=”off” parallax=”off” parallax_method=”off” make_equal=”off” parallax_1=”off” parallax_method_1=”off” column_padding_mobile=”on” custom_width_percent=”40%” custom_margin_last_edited=”off|phone” custom_padding=”||0px|”][et_pb_column type=”4_4″][et_pb_text admin_label=”Texto” background_layout=”light” text_orientation=”left” use_border_color=”off” border_color=”#ffffff” border_style=”solid” header_font_size_phone=”60px” header_font_size_last_edited=”on|phone” module_class=”letra”]<\/p>\n
As proantocianidinas s\u00e3o extra\u00eddas das sementes da uva (vitis vinifera) e s\u00e3o utilizadas por sua capacidade de combater radicais livres. Em numerosos estudos, o extrato demonstrou potencial antioxidante, ainda melhor do que a vitamina E (Hirose, 1984;Maffei, 1994; Uchida, S. 1987 a). As proantocianidinas s\u00e3o de 15 a 25 vezes mais potentes que a vitamina E para neutralizar radicais livres.<\/p>\n
Os radicais livres est\u00e3o relacionados a mais de uma centena de doen\u00e7as em humanos, incluindo artrite, choque hemorr\u00e1gico, aterosclerose, isquemia e reperfus\u00e3o de muitos \u00f3rg\u00e3os, doen\u00e7a de Alzheimer e de Parkinson, disfun\u00e7\u00f5es gastrointestinais, tumores e carcinog\u00e9nese, dentre outras. Subst\u00e2ncias antioxidantes s\u00e3o eliminadores potentes de radicais livres e atuam como inibidores de processos neopl\u00e1sicos.<\/p>\n
Um grande n\u00famero de antioxidantes sint\u00e9ticos e naturais t\u00eam sido usados para melhorar sa\u00fade e prevenir doen\u00e7as. No entanto a atividade, a biodisponibilidade e a efic\u00e1cia terap\u00eautica dos antioxidantes diferem amplamente.<\/p>\n
Proantocianidinas<\/strong>, antioxidantes amplamente dispon\u00edveis em frutas, vegetais, nozes e outras sementes, assim como flores e cascas; possuem um amplo espectro de atividades biol\u00f3gicas, farmacol\u00f3gicas e terap\u00eauticas contra os radicais livres e o estresse oxidativo.<\/p>\n Estudos foram feitos para avaliar a dose necess\u00e1ria de proantocianidinas de semente de uva (GSPE) tanto in vitro in vivo, para eliminar os radicais livres e tamb\u00e9m para comparar a capacidade de elimina\u00e7\u00e3o dos mesmos. Para os estudos foram usados \u00a0GSPE mais vitaminas C, E e beta- caroteno. Estas experi\u00eancias demonstraram que as Proantocianidinas s\u00e3o altamente biodispon\u00edveis e fornecem maior prote\u00e7\u00e3o contra os radicais livres e danos ao DNA, do que as vitaminas C, E e beta-caroteno.<\/p>\n Proantocianidinas tamb\u00e9m demonstraram excelente prote\u00e7\u00e3o para f\u00edgado e rins, nos casos de overdose por paracetamol,possivelmente pela redu\u00e7\u00e3o do estresse oxidativo.<\/p>\n A aplica\u00e7\u00e3o t\u00f3pica de GSPE aumentou o fator de prote\u00e7\u00e3o solar, em volunt\u00e1rios humanos. Estes resultados demonstram que GSPE oferece excelente prote\u00e7\u00e3o contra o estresse oxidativo e les\u00e3o tecidual mediadas por radicais livres.<\/p>\n Ref. Bibliografica:<\/strong><\/p>\n Toxicology. 2000 Aug 7;148(2-3):187-97. O texto acima foi elaborado com base em estudos cient\u00edficos, por\u00e9m salientamos que o conte\u00fado \u00e9 apenas de car\u00e1ter informativo. Antes de adquirir e fazer uso do produto \u00e9 importante consultar um profissional habilitado (seu m\u00e9dico ou nutricionista) ou os farmac\u00eauticos Proderma. Envie um email para\u00a0farmaceuticoresponde@farmaciaproderma.com.br<\/a> ou entre em contato com as nossas lojas pelos telefones (19) 3447-7000 e 3421-2112.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section admin_label=”Se\u00e7\u00e3o” global_module=”25464″ fullwidth=”off” specialty=”off” transparent_background=”on” background_color=”#ffffff” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”off” custom_padding=”0px||0px|” padding_mobile=”on” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”off”][et_pb_row global_parent=”25464″ admin_label=”Linha” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” custom_padding=”||0px|” padding_mobile=”on” allow_player_pause=”off” parallax=”off” parallax_method=”off” make_equal=”off” parallax_1=”off” parallax_method_1=”off” column_padding_mobile=”on”][et_pb_column type=”4_4″][et_pb_text global_parent=”25464″ 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\n Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention.
\n Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG.
\n SourceDepartment of Pharmaceutical and Administrative Sciences, Creighton University School of Pharmacy & Allied Health Professions, 2500 California Plaza, Omaha, NE 68178, USA. debsis@bluejay.creighton.edu<\/p>\nImportante<\/h2>\n
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